Why HPLC Grade Acetonitrile Matters
Acetonitrile (CAS 75-05-8) is the primary mobile phase solvent in reversed-phase HPLC and LC-MS. Its low UV absorbance, low viscosity and high elution strength give clean baselines and sharp peaks. For pharma QC and analytical labs, impurity levels that are invisible in industrial grade become baseline noise in chromatography, so HPLC/LC-MS grade acetonitrile is specified by UV transmittance and gradient performance.
Typical HPLC Grade Specifications
| Parameter | HPLC/LC-MS Grade |
|---|---|
| Purity (GC) | ≥99.9% |
| UV cut-off | ≤190 nm |
| Transmittance at 210 nm | ≥90% |
| Water | ≤0.05% |
| Residue after evaporation | ≤2 ppm |
Main Application Areas
- HPLC / UHPLC mobile phase: Reversed-phase separations in pharma QC, food testing and environmental analysis.
- LC-MS solvent: Low background ions keep mass spectra clean for trace quantification.
- Extraction and recrystallization: Solvent for pharmaceutical and agrochemical intermediates.
- Industrial synthesis: Raw material for nitrile reactions and solvent for polymer processing.
Packaging
HPLC acetonitrile is supplied in 4 L glass/coated bottles, 25 L HDPE jerry cans and 200 L drums, nitrogen blanketed. COA showing UV transmittance and gradient purity per batch, plus SDS, is provided.
View acetonitrile product specifications and request a quote.